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Yoko Matsumoto
Department of Applied Life Sciences, Sojo University, Kumamoto, Japan
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Research Article
Therapeutic Effects of Hybrid Liposomes against Triple Negative Mouse Breast Cancer in vitro and in vivo
Author(s): Hideaki Ichihara*, Suguru Miyamoto, Junna Takai, Masaki Okumura, Koichi Goto and Yoko Matsumoto
Hybrid Liposomes (HL), composed of L-α-dimyristoylphosphatidylcholine (DMPC) and polyoxyethylene (25) dodecyl ether (C12(EO)25), demonstrated significant therapeutic potential against breast cancer cells. HL formed a clear and stable solution with a hydrodynamic diameter of approximately 100nm, which remained unchanged for at least four weeks, suggesting high physicochemical stability suitable for clinical application. In vitro, HL exhibited a marked antiproliferative effect on 4T1-Luc murine breast cancer cells. Furthermore, flow cytometric analysis revealed a significant increase in apoptotic cell populations following HL treatment, indicating that HL effectively induces apoptosis in breast cancer cells. In vivo, administration of HL to 4T1-Luc tumor-bearing mice resulted in a significant reduction in tumor volume and tumor weight, without any observable adverse effects or cha.. View more»