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Mesfin Tafesse
Department of Biotechnology, College of Applied Natural Sciences, Addis Ababa Science and Technology University. P.O. Box, 1617, Addis Ababa, Ethiopia
Publications
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Research Article
Future of Stable Fermentation and Role of Next Generation Bio-sensors
Author(s): Abu Feyisa*, Mesfin Tafesse, Musin Kelel and Gesesse Kebede
The objective of a bioprocess is to bring about particular chemical and/or physical changes in biochemical materials generated from the medium. Typically, a bioprocess will require fully functional live cells or enzymes as the biocatalyst. The possibility of unfavorable cell heterogeneity, which is defined by an increase in the frequency of low producing cells, is common during the scale up of bioprocesses. Low producing cells appear as a result of both genetic and non-genetic variation and will enrich as a result of their faster specific growth rate throughout the prolonged number of cell divisions involved in large scale bio production. The most recent methods for synthetic fermentation stabilization are presented, and it is argued that they should be used to create designs for cell factories that better meet industrial requirements. DNA sequencing information is used to guide strai.. View more»