Pharmaceutica Analytica Acta

Department of Pharmaceutical Chemistry, Prince of Songkla University, Hatyai, Songkhla, Thailand

Publications

• Research Article   
  Molecularly imprinted polymers: Paving the way for Future Drug Delivery Innovations
  Author(s): Roongnapa Suedee*, Watchara Pholsathien, Kanok-on Jaisawan, Jittiya Rodruksa and Pistawus Khomintr
  
  This study investigates environmentally friendly components in Molecularly Imprinted Polymers (MIPs) and their integration into nanocapsules for drug delivery. We developed a novel carrier for MIP-based drugs, enhancing the efficacy of biotherapeutic proteins. Optimizing peptide-based nanospheres with recombinant Fc proteins aims to improve drug delivery efficiency while preserving critical recognition sites. Using X-ray fluorescence microscopy, we analyzed the impact of molecular size and fluctuation movement affect the binding of MIP-based drugs, suggesting that polar additives influence the protein concentrate’s excipient-rich phase. Our drug analysis indicated that the solubility of Cannabidiol (CBD) and monoclonal antibody/insulin combinations increased at 40 °C, which aligns with findings from SEM and thermogravimetric analysis. HPLC-UV and LCMS/MS studies showed effec.. View more»
  

  Abstract PDF