Pharmaceutica Analytica Acta

Abstract

Molecularly imprinted polymers: Paving the way for Future Drug Delivery Innovations

Roongnapa Suedee*, Watchara Pholsathien, Kanok-on Jaisawan, Jittiya Rodruksa and Pistawus Khomintr

This study investigates environmentally friendly components in Molecularly Imprinted Polymers (MIPs) and their integration into nanocapsules for drug delivery. We developed a novel carrier for MIP-based drugs, enhancing the efficacy of biotherapeutic proteins. Optimizing peptide-based nanospheres with recombinant Fc proteins aims to improve drug delivery efficiency while preserving critical recognition sites. Using X-ray fluorescence microscopy, we analyzed the impact of molecular size and fluctuation movement affect the binding of MIP-based drugs, suggesting that polar additives influence the protein concentrate’s excipient-rich phase. Our drug analysis indicated that the solubility of Cannabidiol (CBD) and monoclonal antibody/insulin combinations increased at 40 °C, which aligns with findings from SEM and thermogravimetric analysis. HPLC-UV and LCMS/MS studies showed effective binding and release of antibody Complementarity Determining Region (CDR) peptides in our delivery system, with a correlation between rapid-release phases and elevated CBD concentrations facilitating protein reabsorption through HSA-imprinted receptors. Higher CBD concentration with anti-IgE antibodies and insulin minimizes target depletion, enhancing CDR persistence and efficacy. The improved drug delivery via nanocapsules enhances FcRn functionality while preserving protein integrity, highlighting its potential for treating chronic diseases and improving patient convenience.

Published Date: 2025-08-19; Received Date: 2025-07-19