Journal of Clinical & Experimental Pharmacology

Department of Non-communicable Disease, Translational Health Science and Technology Institute, Faridabad, Haryana, India

Publications

• Original Research Article   
  Herbal Constituents of AYUSH-64 Formulation Modulate Release of Cytokines in TLR7/8-Induced Macrophage-Like Cells
  Author(s): Kamala Priya, Manisha Dagar, Madhu Dikshit* and Ajay Kumar*
  
  Recent insights into the pathophysiology of COVID-19 have revealed a significant relationship between Cytokine Release Syndrome (CRS) and the disease’s severity, characterized by elevated levels of cytokines such as TNF- α, IL- 1β, IL-6, and IL-10. In this study, we simulated virus recognition through TLR7/8 receptors and the subsequent inflammatory response using imiquimod and resiquimod within PMA-differentiated THP1 macrophage-like cells. We investigated the prophylactic potential of herbal constituents found in the AYUSH-64 formulation, including Alstonia scholaris, Picrorhiza kurroa, Swertia chirata, and Caesalpinia crista, to modulate gene expression and secretion of inflammatory cytokines in induced cells. Our findings were compared with the previously reported effects of the AYUSH-64 formulation in a similar TLR7/8-.. View more»
  

  DOI: 10.35248/2161-1459.23.13.394

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