Journal of Clinical & Experimental Pharmacology

Vijay M Kale

Publications

• Research Article
  Quercetin Protects Rat L6 Myocytes from Antimycin A-Induced Mitochondrial Dysfunction
  Author(s): Vijay M KaleVijay M Kale
  
  Objective: Mitochondrial dysfunction is often associated with various disorders such as diabetes, Alzheimer?s etc. Reactive oxygen species (ROS), aging, and reduction of mitochondrial biogenesis contribute to mitochondrial dysfunction. Antimycin-A (AMA) damages the mitochondria through inhibition of mitochondrial electron transport. The present study sought to investigate effects of quercetin on rat L6 cells and whether quercetin protects mitochondria against oxidative damage caused by AMA. Methods: Rat L6 myocytes were used for the study. Effects of quercetin on Antimycin-A induced mitochondrial dysfunction was studied using cytotoxicity, ATP levels, mitochondrial superoxide production and NDUFB8 mRNA expression. Results: In this study, exposure of L6 myocytes to AMA induced an increase cell death, decreased ATP content, followed by a decrease in mitochondrial superoxide, and decreased .. View More»
  DOI: 10.4172/2161-1459.1000202

  Abstract PDF