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Updated clinical indications of immunomodulators: Role in SARS-CoV-2
36th World Congress on Pharmacology
July 25, 2023 | Webinar
Bimal Roy Krishna
Touro University Nevada, USA
Keynote: J Clin Exp Pharmacol
Abstract:
Immunomodulators have shown great promise in regard to prevention and treatment of various disorders ranging from autoimmune, inflammation, rheumatoid arthritis, Crohn’s Disease and infectious diseases. The global pandemic of 2020 related to SARS-CoV-2 or Coronavirus, saw the protective role of immunomodulators in reducing disease severity and in improving recovery. Several agents exist with different mechanisms of action, indications and side effect profiles. The two general categories are Immunosuppressive and Immunostimulatory agents. The goal has been to increase immune system specificity while minimizing toxicity peripherally and to other organs. Infectious diseases are considered immunological disorders and neoplastic diseases are involved in an immunosuppressive state. Immunomodulators are able to stimulate natural and defensive mechanisms which are of potential clinical benefit. While they are highly beneficial, their side effects and toxicity profile can often limit their use. There are also potential drug interactions. This presentation summarizes a number of immunomodulators with their clinical indications, mechanism of action and toxicity profiles. It also provides an overview of their role in the treatment of SARS-CoV-2.
Biography :
Bimal Roy Krishna currently holds the position of Professor and Director of Pharmacology and Chair-SPC at the College of Osteopathic Medicine-Touro University Nevada. He has been Adjunct Professor of Pharmacology for Kaplan Medical for the past 12 years where he has been actively involved in Step-1 USMLE and COMLEX reviews throughout the USA and in Mexico, Caribbean, Poland, India, UAE, South America and Saudi Arabia. In addition he is an Adjunct and Visiting Professor at various other national and international institutions.