Clinical Microbiology: Open Access

The possible role of prostaglandin D2 in malaria pathogenesis

6^th Clinical Microbiology Conference

October 20-22, 2016 Rome, Italy

Pimwan Thongdee, Jiraporn Kuesap and Kesara Na-Bangchang

Thammasat University, Thailand

Posters & Accepted Abstracts: Clin Microbiol

Abstract:

Prostaglandin D2 (PGD2) is the most crucial prostanoid produced in the brain and involved in pain responses. Moreover, PGD2 is a key factor derived from malaria within erythrocytes and might influence to parasite growth. The aim of the study was to preliminarily investigate the role of PGD2 in malaria pathogenesis. Blood samples were collected from patients with Plasmodium vivax and Plasmodium falciparum (moderate and high parasitemia: 1000-50000 and >50000/μl, respectively) infections, patients with fever associated with other infections and healthy subjects of both genders and all age groups. PGD2 concentrations were determined using Prostaglandin D2-MOX express EIA kit (Cayman Chemical, USA). Median (range) of plasma PGD2 concentrations in patients with fever associated with other infections, patients with P. vivax and patients with P. falciparum infections and healthy subjects (control) were 60 (11-525), 34 (22-130), 28 (16-38), 22 (13-75) and 16 (6-30) pg/ml, respectively. The median (range) plasma PGD2 concentrations in patients with fever associated with other infections was significantly higher than those with P. vivax (p<0.05), P. falciparum infections with moderate parasitemia (p<0.0001) and healthy subjects (p<0.0001). The concentrations in patients with P. vivax infection was significantly higher than those with P. falciparum with moderate parasitemia (p<0.0001) and healthy subjects (p<0.0001). Results of this preliminary study may suggest at least in part, an involvement of PGD2 in fever-associated infections including malaria. Confirmation of this finding is required with a larger sample size.

Biography :

Pimwan Thongdee has completed her PhD from Thammasat University, Thailand. She is a Product Specialist at i+MED Laboratories Company Limited. She has published 3 papers in reputed journals.

Email: pimwant@gmail.com