Journal of Clinical & Experimental Pharmacology

Synthesis and antimalarial activities of poly ethylene glycol derivatives of dihydroartemisinin

3^rd World Congress on Pharmacology

August 08-10, 2016 Birmingham, UK

Junior Kindala T, Ezekiel Afolabi O, Noel Wannang N, Kalulu Taba M and Jean Kayembe S

University of Kinshasa, DR Congo

Posters & Accepted Abstracts: Clin Exp Pharmacol

Abstract:

Despite decades of effort to eradicate or at least control malaria, it remains endemic in all six WHO regions and the burden is heaviest in the African Region, where an estimated 90% of all malaria deaths occur; according to WHO, two countries �?? the Democratic Republic of the Congo and Nigeria �?? account for about 40% of estimated mortality due to malaria worldwide. The most recent additions to the drug therapy for malaria are artemisinin. However the therapeutic value of artemisinin is limited to a great extent by its low solubility in both oil and water. In the search for more effective and soluble drugs, a number of ether derivatives of dihydroartemisinin have been synthesized. The use of ethers of dihydroartemisinin and artemisinin itself in the treatment of Plasmodium falciparum malaria is restricted by their short plasma half-life. A search for new artemisinin derivatives with a better therapeutic index due to a better solubility and bio-availability has thus become an important target of many laboratories around the world. For this reason we prepared a new class of artemisinin derivatives using 4-Arm PEG-COOH and 8-Arm PEG-COOH (PEGDHA); which are known for their high flexibilities, hydrophilic property and low toxicity. It is our belief that successful development of PEG-DHA via this study will reduce considerably the dosage regime of the artemisinin derivative, so that patient compliance will be easier.

Biography :

Email: juniorkind@yahoo.fr