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Simultaneous analysis of diuretic drugs in food and dietary supplements using LC/PDA and LC/MS/MS
15th International Conference on Food Processing & Technology
October 27-29, 2016 Rome, Italy
Hye Soon Kang, Hyung-Il Kim, Moo-Song Lim, Joong-Hoon Cho, Chul-Joo Lim and Sun-Ok Choi
Gyeongin Regional Food and Drug Safety, South Korea
Posters & Accepted Abstracts: J Food Process Technol
Abstract:
Diuretic drugs such as chlorothiazide, hydrochlorothiazide, hydroflumethiazide, trichloromethiazide and methylchlothiazide are illegal to be included in food and dietary supplements since abuse intake of the drugs via food without medical prescription can be caused life-threatening side effects. Governmental agencies of food and drug safety invest their efforts to screen out food and dietary supplements illegally containing diuretic drugs. We developed an accurate, simple, rapid and simultaneous analysis method of five thiazide diuretic durgs in food and dietary supplements using liquid chromatography coupled with photodiode array detection (LC/PDA). The developed method was fully validated and showed good results with respect to specificity, linearity (r2>0.99), limit of detection (0.1μg/mL), limit of quantification (0.4μg/mL), precision (RSD<3.3%), recovery (92.1~106.4%), and reproducibility. It also satisfied all standards suggested by AOAC for the analysis of diuretic drugs in food and food supplements. To confirm the detected antiobesity drugs in food and dietary supplements, we also developed a qualitative analysis method by Liquid chromatography coupled with mass spectrometry (LC/MS). Ninety foods and dietary supplements purchased by internet and local market in Korea were tested with the developed method. Diuretic drugs were not detected in all samples. LC/PDA and LC/MS methods described in this study were simple, rapid and reliable; the methods may be suitable for a rapid and sensitive analysis of chlorothiazide, hydrochlorothiazide, hydroflumethiazide, trichloromethiazide and methylchlothiazide simultaneously in food and dietary supplements.
Biography :
Hye Soon Kang is a Scientific Officer in Gyeongin Regional Food and Drug Safety of Ministry of Food and Drug Safety in Korea.
Email: erclo@korea.ac.kr