Clinical Microbiology: Open Access

Role of interleukin-10 gene promoter polymorphism in the severity of group A Streptococcus infection

6^th Clinical Microbiology Conference

October 20-22, 2016 Rome, Italy

Amr Abdou

National Research Center, Egypt

Posters & Accepted Abstracts: Clin Microbiol

Abstract:

Group A Streptococci (GAS) with several virulence factors contributing to their pathogenesis are responsible for a variety of human illnesses. The variability of illnesses from mild uncomplicated infections to severe invasive diseases proposes that host genetic variation is the determining factor that modulates disease manifestations and outcomes. Unbalanced inflammatory response against streptococcal super antigens (Strep-SAgs) with avalanche of cytokine release is the main reason for severe manifestations. Interleukin 10 (IL-10), a Cytokine Synthesis Inhibitory Factor (CSIF), plays a pivotal role in controlling the process of inflammation. The production of IL-10 is controlled by 3 Single Nucleotide Polymorphisms (SNPs) in the promoter region, -1082G/A, -819C/T and -592C/A. The association of these SNPs with the severity of GAS infection was investigated. Alleles and haplotypes, known to be associated with low production of IL-10, were found to be more represented in individuals that were subjected to early death due to GAS infection.

Biography :

Email: amrkheir@yahoo.com