Clinical Microbiology: Open Access

Prevalence and impact of hepatitis C virus coinfection amongst people living with human immunodeficiency virus in era of HAART regimen

Joint Event on 8^th Annual Congress on CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES & 13^th World Congress on VIROLOGY, INFECTIONS AND OUTBREAKS

December 05-06, 2018 | Vancouver, Canada

Theophilus Kachi Udeani and Uchechukwu Judit Umeha

University of Nigeria, Nigeria

Posters & Accepted Abstracts: Clin Microbiol

Abstract:

The co-infection of hepatitis C and human immunodeficiency viruses increases the progression the combined antiretroviral therapy. This cross-sectional study investigated the prevalence of hepatitis C virus infection in HIV infected persons on combined antiretroviral therapy. The participants were selected by random sampling and information on demographic characteristics and social lifestyles were obtained using a structured questionnaire. Anti-HCV antibodies were detected by 4th generation EIA while ALT and creatinine and CD4+T-cells values were estimated. The data obtained were analyzed using the chi-square test at p???0.05. A total of 186 HIV infected person were enrolled for the study with a mean age of 38.00+12.4-year-olds and 5.4% were HCV-infected. The males and had equal seropositivity of 2.7% (5/186) each while the age group above 40 years accounted for 3.2% (6/186) The seropositivity of HCV was higher among married couples, 4.8% (9/186). The risk factors for HCV/HIV co-infection indicated that none of the statistically significant but blood transfusion accounted for 0.5% (1/186). The CD4 T not statistically significant on HCV infection. The ALT values indicated that majority of the HCV/HIV co-infected patients were of normal values, while creatinine values were statistically significant in the outcome of HCV/HIV co-infection. At elevated values of 117.37+5.25?mol/l, 7.3% HCV infected participants were in this group, RR[(95%CI (7.5, 3.01-18.68)] p=0.001. In conclusion, HCV/HIV coinfected patients with elevated creatinine levels are at risk of developing renal failure.

Biography :

E-mail: theophilus.udeani@unn.edu.ng