Journal of Neonatal Biology

Prediction Score in Neonates admitted with Meconium aspiration syndrome in NICU: A Cohort Study

International Conference and Expo on Neonatology and Perinatology - June 06, 2022 | Webinar

June 06, 2022 | Webinar

Siddu Charki

Dept of Pediatrics, BLDE (DU) Shri B M Patil Medical College Hospital and Research Centre, India

Scientific Tracks Abstracts: J Neonatal Biology

Abstract:

Background and Objective: With improved survival in neonates with meconium aspiration syndrome (MAS), the focus is currently on reducing morbidities. The objective of this study was to predict factors determining prolonged hospital stay in neonates with MAS. Materials and methods: It is a retrospective cohort from BLDE (DU) Shri B M Patil Medical College Hospital and research Centre, Vijayapura, Karnataka, India between 2019 and 2021. Neonates �?35 weeks of gestation admitted to NICU with the diagnosis of MAS and requiring oxygen beyond 24 hours of life were included in the study. The morbidities in neonates with stay ≤7 days (short stay) were compared with >7 days (prolonged stay). Logistic regression by the backward stepwise method was used for predictive score creation. Results: Out of 347 babies with MAS discharged home, 103 (29%) babies had a short stay and 244 (71%) babies had prolonged stay. The primary support beyond O2 (42% vs 83%, p<0.001), FiO2 at 1hr>30% (45% vs 87%, p<0.001), HIE stage 2 or 3 (2% vs 27%, p<0.001), moderate- severe PPHN (3% vs 31%, p<0.001) were independent factors associated with prolonged stay on logistic regression. A prediction model was devised using weighted scores of these four associated morbidities. The clinical score thus developed had 83% sensitivity, 68% specificity for the prediction of prolonged stay [AUC- 82, 95% CI (78-87), p<0.001]. Conclusion: More than two-thirds of babies with MAS have prolonged stay. The primary support beyond oxygen, Fio2 requirement >30%, Moderate to severe PPHN, HIE stage 2 or 3 were predictive of prolonged stay in neonates with MAS.

Biography :

Dr. Siddu Charki, MBBS, MD Paediatrics, holds an IAP fellowship in neonatology. Paediatric advanced training in accordance with American Heart Association standards, Bangalore; Neonatal resuscitation programme at St. Johns medical college, Bangalore; Neonatal Functional Echocardiography and Neurosonogram at Manipal Hospital, Bangalore; Developmental Supportive Care in NICU at St. Johns medical college, Bangalore; Neonatal Emergencies Simulation Training [NEST TOT] at OVUM Hospital, Bangalore; Whole Body Cooling [Therapeut] at OVUM Hospital, Bangalore; completed 108 babies with a good neurodevelopment outcome at 18 month follow up and inhaled Nitric Oxide therapy in neonates with PPH.