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Powder topical Rifampicin on reducing infections after Neural Tube Defect (NTD) surgery in infants
9th International Conference on Neonatology and Pediatric Neurology
November 28-30, 2016 Valencia, Spain

Nihat Demir, Erdal Peker, Ismail GülSen, Selami Kocaman, Oguz Tuncer and Ercan Kırımi

Wayne State University, USA
Yuzuncu Yil University, Turkey

Posters & Accepted Abstracts: J Neonatal Biol

Abstract:

The correct timing and technique of neural tube defect (NTD) repairs significantly decreases the morbidity and mortality of NTD cases. However, infections related to the surgery are still common. We investigated the effects of topical rifampicin (RIF) combined with routine prophylaxis in newborns with open NTD. Eighty-six (86) patients who had undergone NTD surgery were included in the retrospective study. Thirty (30) patients who started on topical RIF before surgery made up the study group, and 56 cases that were not administered topical RIF made up the control group. Surgical site infections (SSIs) and meningitis/ ventriculoperitoneal (VP) shunt infections that developed within 6 months after the surgical intervention were evaluated. In the post-operative period, meningitis/VP shunt infections were observed in 6.7% and SSI in 3.3% of the experimental group treated with topical RIF, while meningitis/VP shunt infections were observed in 37.5% and SSIs in 21.4% of the control group. External ventricular drainage and not using topical RIF were identified as important risk factors for meningitis/VP shunt infections [RR 19,28 (3,53-105,33), p=0.001; RR 18,10 (2,38-137,68), p=0.005, respectively]. A flap transposition, cerebrospinal fluid (CSF) leaks and not using a topical RIF were identified as relative risk factors for SSIs [RR 22,21 (4,81-102,47), p<0.001; RR 13,04 (1,22-139,33), p=0.034; RR 7,09 (1,12-53,99), p=0.042, respectively]. We did not observe any local or systemic side effects duo to the use of RIF. The use of topical RIF is an easy and effective method for reducing SSIs and meningitis/VP shunt infections related to NTD surgery.

Biography :

Email: demirnihat27@hotmail.com

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