Journal of Clinical & Experimental Pharmacology

Intranasal voriconazole-loaded nanoemulsion for enhanced therapy of cryptococcal meningitis

37^th World Congress on Pharmacology

October 31- November 01, 2024 Webinar

Bhupendra G Prajapati

Ganpat University, India

Keynote: J Clin Exp Pharmacol

Abstract:

Statement of the Problem: Cryptococcal meningitis is a fungal infection which mainly impacts the membrane enveloping the brain and spinal cord. Voriconazole is known to have promising therapeutic agent for treatment of fungal infection which is commercially available in both oral and intravenous administrations. In this study, the voriconazole-loaded nanoemulsion formation was developed with the aim to enhance the brain delivery via nasal administration for the treatment of cryptococcal meningitis. Methodology and Theoretical Orientation: The selection of optimal composition of Oleic acid, Tween 80 and Transcutol P as oil phase, surfactant, and co-surfactant was performed using pseudo-ternary phase diagrams. The results of physicochemical characterization showed that the selected formulations exhibited small droplet size, low polydispersity, adequate zeta potential, etc. Findings: The high %encapsulation efficiency of the nanoemulsion formulations was observed (93.53 to 97.65%). The nanoemulsions also showed good physical stability under different stress conditions. The release study showed the biphasic release behaviour of the formulation with about 97.57% of cumulative drug release after 120 min exhibited by optimized formulation. Additionally, cytotoxicity assessment revealed no adverse effects on nasal epithelial cells, indicating the safety of the optimized formulation. Conclusion and Significance: These findings highlight the potential of the developed nanoemulsion as a noninvasive and effective treatment option for fungal infections, offering advantages over conventional oral and intravenous formulations.

Biography :

Bhupendra Prajapati is a Professor in Department of Pharmaceutics, Shree S K Patel College of Pharmaceutical Education and Research, Ganpat University, Gujarat, India and Adjunct Professor Silpakorn University, Thailand. He has 22 years of academic and research experience and published more than 250 researches and review works in international and national Journals. He has delivered invited scientific talk in many conference and seminar worldwide. He authored 150 book chapters in the field of novel drug delivery. He edited 20 books with publishers like Elsevier, AAP CRC, Wiley, Springer and Jenny Stanford. He is a reviewer in many high impact journals and is on the editorial board member.