Journal of Food Processing & Technology

High-fructose diet induces testicular degeneration in rat

World Food Science & Technology Congress

October 15-16, 2018 Athens, Greece

Onur Gokhan Yildirim,Esra Sumlu, Esra Aslan, M Bilgehan Pektas,Gokhan Sadi and Fatma Akar

Artvin Coruh University, Turkey
Gazi University, Turkey
Afyon Kocatepe University, Turkey
Karamanoglu Mehmetbey University, Turkey

Scientific Tracks Abstracts: J Food Process Technol

Abstract:

The growing worldwide epidemic of metabolic syndrome may be linked to an increased consumption of fructose. High-fructose diet is well documented to induce metabolic disturbances in animal and human studies. The effect of high-fructose diet on male reproductive system has been poorly documented. Therefore, herein, we investigated the effects of dietary fructose on testicular function regulators IGF-1R and c-kit, bloodtestis barrier proteins claudin-1 and pan-cadherin in the testis of rats. Fructose was given to the rats as 20% solution in drinking water for 15 weeks. Histological examination with hematoxylin-eosin staining showed that dietary fructose caused degeneration in seminiferous tubules. Also, testicular concentration of testosterone was decreased. The expression level of IGF-1R protein measured by both Western blotting and immunohistochemical staining was increased in testicular tissue of fructose feeding rats. Our immunostaining study also demonstrated that expression intensities of c-kit, claudin-1 and pan-cadherin were comparable in seminiferous tubules of control and fructose-treated rats. In conclusion, high-fructose ingestion induces a testicular degeneration together with increased expression level of IGF-1R in testicular tissue of rats, thus showing a compensatory defense mechanism against harmful challenge.

Biography :

Onur Gokhan Yildirim is currently pursuing his PhD in the Department of Pharmacology, Faculty of Pharmacy at Gazi University. His research subjects focus on the effects of fructose consumption-induce metabolic syndrome and its modulation of dietary factors. He has published three SCI papers in related subject.

E-mail: onurgokhan08@hotmail.com