Journal of Advanced Chemical Engineering

Harnessing C(sp3)-metal for cross-coupling reaction

Joint Event 19^th European Organic Chemistry Congress 10^th International Conference on Physical and Theoretical Chemistry

November 07, 2023 | Webinar

Liang-An Chen

Nanjing Normal University, China

Scientific Tracks Abstracts: J Adv Chem Eng

Abstract:

Transition metal-catalyzed cross-coupling reactions involving organometallic reagents have emerged as a practical technical for intruding saturated carbon skeleton into organic molecules. However, the cross-coupling often suffered from the use of preprepared organometallic reagents with additional tedious synthetic steps, which are often sensitive to water and air, thus requiring exceptional caution for preservation. Stoichiometric organometallic reagents are often required for the cross-coupling reaction, thus resulting in poor atom economy. To the best of our knowledge, most coupling reactions employed C(sp2)- or C(sp)-metal reagents. By contrast, the method for accessing alkyl metal species (C(sp3)-M) is still a significant challenge; furthermore, they are prone to undergo β-H elimination or homolytic cleavage. Therefore, harnessing C(sp3)-M for transition metal-catalyzed coupling reaction represents a daunting challenge. Herein, we will report our recent contribution to transition-metal catalyzed cross-coupling reactions using in situ generated catalytic C(sp3)-M as a key intermediate, featuring high step- and atom-economy.

Biography :

Liang-An Chen received his PhD with Prof. Eric Meggers at Xiamen University in 2014. He began postdoctoral research with Prof. James Leighton at Columbia University (2015-2018), then joined Indiana University (Bloomington) as a postdoctoral fellow with Prof. Kevin Brown (2018-2019), and started his independent academic career at Nanjing Normal University as a professor of chemistry (7/2019). His research interest focuses on transition metal catalysis, synthetic methodology, and asymmetric catalysis.