Journal of Neonatal Biology

Gram negative sepsis in term and preterm infants: Aetiologies and clinical outcomes

9^th International Conference on Neonatology and Pediatric Neurology

November 28-30, 2016 Valencia, Spain

Moloney DM and Dempsey E

University College Cork, Ireland

Posters & Accepted Abstracts: J Neonatal Biol

Abstract:

Background: Neonatal septicemia is a source of extensive morbidity and mortality. The aim is to evaluate the outcome and aetiology of every episodes of gram negative sepsis in the neonatal population of Cork University Hospital (CUH) over the past 8 years. Methods: This is a retrospective descriptive analysis. Neonates with blood cultures with gram negative growth were identified from microbiology database in CUH. Results: 50 babies with 51 episodes of Gram negative sepsis were included in the study. The majority of sepsis occurred after the first 72 hours of life (41; 80.3%), i.e. late onset sepsis. Mean gestation was 29 weeks, 3 days and mean birth weight was 1357 g. The majority of neonates in this group were <32 weeks i.e. very premature (37; 74%). The incidence of Gram negative sepsis was 5.3% for neonates less than 32 weeks. The most common pathogen was Escherichia coli (34; 66%) followed by Klebsiella spp. (15; 29%). There were 2 instances of extended spectrum beta lactamase (ESBL). Mortality was 10%. There was no difference in gestational age, birth weight or blood parameters (CRP, WCC and Platelets) between those who survived or died. Chorioamnionitis and sepsis occurring in the first 72 hours of life are associated with mortality (p=.018, p=.047). A diagnosis of periventricular leukomalacia was associated with a higher C-reactive protein on day 0 and day 7 of sepsis (p=.028 and p=.043). Conclusion: E. coli remains the most common Gram negative pathogen in the NICU and early onset disease is associated with significant risk of mortality.

Biography :

Email: 111332391@umail.ucc.ie