Journal of Clinical & Experimental Pharmacology

Evaluation of Pseudocerastes persicuss venom on cancer cells

5^th International Conference and Exhibition on Pharmacology and Ethnopharmacology

March 23-25, 2017 Orlando, USA

Zahra Salehi-Najafabadi, Mahnaz Sajadi and Hamidreza Goudarzi

Razi Vaccine and Serum Research Institute, Iran
Agricultural Research Education and Extension Organization, Iran
Tofigh Daru Research and Engineering Co., Iran

Posters & Accepted Abstracts: Clin Exp Pharmacol

Abstract:

Snake venom is a complex mixture of enzymatic and non-enzymatic peptides and proteins with specific chemical and biological activities that can be used in the treatment of many medical conditions such as cancer. Snake venom cytotoxicity can potentially destroy the tumor cells. Various enzymes isolated form snake venom have anti-tumor properties such as MetalloProteinase (MPs), L- amino Acid Oxidase (LAAOs), C-type lectins and phospholipases A2 (PLA2s). These enzymes manage different mechanisms of action. PLA2s have direct toxic action; LAAOs generates free radical; PLA2s, MP, and LAAOs induce apoptosis; and disintegrins and lectins cause antiangiogenesis. Due to the special geographical situation of Iran, this country is suitable habitat of many snakes from different families. The Persian horned viper (Pseudocerastes persicus) belongs to family Viperidae and is found in different province of Iran, Pakistan, Afghanistan, Oman and Iraq. The same as other vipers, the venom of this snake shows the strong hemorrhagic activity. However, few studies have been made on the pharmacological activity of Pseudocerastes persicus venom. In this study, we investigated for the first time that the venom of Pseudocerastes persicus is cytotoxic to tumor cells and inhibits proliferation of human breast cancer cell lines MCF-7 and lung cancer cell lines A459.

Biography :

Zahra Salehi Najafabadi is an Assistant Professor of Razi Vaccine and Serum Research Institute, Iran.

Email: zahra.salehi@live.com