Journal of Nanomedicine & Nanotechnology

ENG-LPHNp???engineering of lipid-polymer nanoparticles loaded with cardiovascular drugs for biomedical applications

Joint Event on 28^th International Conference and Expo on Nanoscience and Nanotechnology & 3^rd World Congress and Expo on Graphene & 2D Materials

November 26-28, 2018 | Barcelona Spain

Pavaloiu Ramona-Daniela, Shaat Fawzia, Bubueanu Corina, Hlevca Cristina and Berger Daniela

Politehnica University of Bucharest, Polizu, Romania
INCDCF-ICCF Bucharest, Romania

Posters & Accepted Abstracts: J Nanomed Nanotechnol

Abstract:

Lipid-polymer nanoparticles (LPHNp) are an interesting class of drug delivery systems displaying advantages of both liposomes and polymeric nanoparticles while limiting their drawbacks, like high stability, high carrier capacity, nanometric size and excellent biocompatibility. The objective of this study was the engineering of LPHNp loaded with cardiovascular drugs and their evaluation for monotherapy and/or bitherapy. LPHNp were prepared via nanoprecipitation method using poly (D, L-lactide-co-glycolide) (PLGA)???polymeric matrix, pluronic F127???stabilizer and phosphatidylcholine lipid. Angiotensinconverting enzyme (ACE) inhibitors (perindopril), diuretics (indapamide), angiotensin II receptor antagonist (valsartan) and calcium channel blocker (amlodipine) were used as cardiovascular drugs. LPHNp were loaded with a single cardiovascular drug or a combination of two drugs (perindropril-indapamide; valsartan-amlodipine). LPHNp were assessed in terms of entrapment efficiency and size. Also, in vitro drug release studies were performed by using a dialysis membrane method and several models (zero-order, first order, Higuchi and Hixson-Crowell) were applied to evaluate the in vitro drug release data. Obtained nanoformulations presented good entrapment efficiency, small sizes and the in vitro release study showed a slow release of drugs. These results suggest that lipid-polymer nanoparticles could be exploited as drug carriers for cardiovascular drugs. Further studies will be performed to demonstrate the therapeutic effect.

Biography :

Păvăloiu Ramona-Daniela is currently a Postdoctoral Researcher at the Faculty of Applied Chemistry and Materials Science, University Politehnica of Bucharest and also at the National Institute For Chemical-Pharmaceutical Research and Development–ICCF Bucharest. She is a Member of 11 research projects (two as Project Manager); 14 publications (six ISI papers as First Author; five ISI papers as Co-Author, three publications in BDI journals); one book chapter; three patents, seven patent applications; two contributions in conference proceedings; 25 communications at international and national conferences and 29 citations. Her expertise lies in innovative drug delivery systems-liposomes, nanoparticles, drug release and mathematical modeling of drug release

E-mail: pavaloiu_daniella@yahoo.com