Clinical Microbiology: Open Access

Biological activities of lanthanide (III) nitrate complexes with N-(2-hydroxynaphthalen-1-yl) methylene) nicotinohydrazide Schiff base

6^th Clinical Microbiology Conference

October 20-22, 2016 Rome, Italy

Waleed M H Al-Momani and Ahmed K Hijazi

Jordan University of Science and Technology, Jordan
Al-Balqaa' Applied University, Jordan

Posters & Accepted Abstracts: Clin Microbiol

Abstract:

The field of coordination chemistry has registered a phenomenal growth during last few decades. It is well known that precious metals have been used for medicinal purposes for at least 3500 years. At that time, precious metals were believed to benefit health because of their rarity, but research has now well established the link between medicinal properties of inorganic drugs and specific biological properties. The current study was designed to explain the synthesis and characterization of the lanthanide (III) nitrate complexes with N-(2-hydroxynaphthalen-1-yl) methylene) nicotinohydrazide Schiff base and to evaluate the antibacterial and the antioxidant activities of the Schiff base and its lanthanide ion complexes. Antimicrobial activity of the lanthanide (III) nitrate complexes with N-(2-hydroxynaphthalen-1-yl) methylene) nicotinohydrazide Schiff base was estimated by minimum inhibitory concentration (MIC, μg/mL) using a micro-broth dilution method for different clinical isolates such as Eschereshia coli and Enterococcus faecalis. Our present study has shown that moderate antimicrobial activity exists against both ligand and its complexes. There was no significant difference between Gram-positive and Gram-negative bacteria towards the tested ligand and its complexes. The results obtained herein indicate that the ligand and its complexes have a considerable antibacterial activity.

Biography :

Email: waleed.almomani@bau.edu.jo