Journal of Clinical & Experimental Pharmacology

Alpha boswellic acid alleviates the effect of irritants causing gastric ulcer disease in ethanol induced ulcer model in mice

36^th World Congress on Pharmacology

July 25, 2023 | Webinar

Reem T. Attia

Future University in Egypt, Egypt

Posters & Accepted Abstracts: J Clin Exp Pharmacol

Abstract:

Gastric ulcer, also known as a peptic ulcer, is a prevalent gastrointestinal condition worldwide. It is characterized by the formation of open sores or ulcers on the lining of the stomach. Gastric ulcers can be caused by various factors, including infection with the bacterium Helicobacter pylori, long-term use of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs), excessive alcohol consumption and stress. Globally, the prevalence of gastric ulcers varies across different regions and populations. According to the World Gastroenterology Organization, peptic ulcer disease affects approximately 10% of the world's population at some point in their lives. The incidence and prevalence of gastric ulcers have shown some variations in different countries and regions. It is important to note that gastric ulcers can have serious complications if left untreated, including bleeding, perforation and obstruction. Therefore, early diagnosis, appropriate treatment and preventive measures are crucial in managing this condition and reducing its burden globally. This research aims to investigate the capacity of alpha boswellic acid extract on the alleviation of the occurrence of gastric ulcer against ethanol induced gastric ulcer in mice. The histological analysis of the gastric tissue showed a significant difference between the untreated groups of mice when compared to the treated group with the ABA extract at the dose of 200 mg/kg. Moreover, the treated group showed down regulation in the proinflammatory TNF-α compared to the untreated control. However, the effect of the ABA extract showed an up regulation of the EGF and TGF-β. In conclusion, ABA extract can be further tested for its role in mitigation of gastric ulcer incidence.

Biography :

Reem T. Attia, PhD, is an enthusiastic pharmacologist, researcher and lecturer. Her research is mainly focused on the pharmacological effect of newly synthesized anticancer drugs, In addition to the effect of nutraceuticals on the alleviation of diseases such as obesity and diabetes. Moreover, she likes to study the effect of anti-inflammatory medications and to develop methods of prevention of their side-effects on the patients. Finally, she is so passionate about the new interactive methods of education and she experiment with various educational tactics in her classroom.