Clinical Microbiology: Open Access

A novel approach for the development of surfactant free polymeric nanoemulsions

Joint Event on 17^th International Conference on Pharmaceutical Microbiology and Biotechnology & 23^rd Edition of International Conference on Immunology and Infectious Diseases

April 29-30, 2019 London, UK

Asad Ur Rehman

University of Strasbourg, France

Posters & Accepted Abstracts: Clin Microbiol

Abstract:

Nanoemulsions (NE) are fine, clear oil-in-water or water-in-oil dispersions stabilized by an amphiphilic surfactant, with droplet sizes < 200 nm. NE are generally prepared in the presence of surfactants to reduce interfacial tension and enhance the stability of NE over time by stabilizing adsorption at the oil/water interface through electrostatic and/or stearic repulsions. But there are some limitations of using surfactants in the formulations like high cost, questionable biocompatibility, interaction with continuous and dispersed phases, formation of interconnected network with the polymer at the interface and alteration of nanoparticle properties (like particle size, zeta potential, polydispersity index, surface hydrophobicity/hydrophilicity etc). To deal with this problem, we have explored the development of NE by spontaneous emulsification, in the absence of surfactant, by using a non-ionic polymer Poly (maleic anhydride-alt-1-octadecene) (PMAO). The first part of the study deals with the chemical treatment of the non-ionic polymer PMAO to render it the amphiphilic properties, followed by the preparation of NE by spontaneous emulsification process. In the 2nd part of the study, process optimization for NE has been performed based on the size distribution of nano- droplets in relation with the polymer/oil ratio (POR), nature of oil and the chain length of Jeffamine polyetheramine (i.e., Jeffamine-1000 and Jeffamine-2000). Along with the above mentioned study, a comparative study has been performed using the monomer, Octadecyl succinic anhydride (OSA), (instead of polymer) keeping the rest of the parameters constant, to observe in parallel the relative abilities of the monomer and polymer to form NE in the absence of surfactant. This study may have very important implications in the development of surfactant free pharmaceutical grade and food grade polymeric nanoemulsions by spontaneous emulsification. And such systems can be used as template for preparation of polymeric nanoparticles, suitable for biomedical application.

Biography :

E-mail: asadurrehman.sher@yahoo.com