Assistant Professor, Yong Loo Lin School of Medicine
National University of Singapore, Singapore
After completion of his Ph.D research in Cellular Immunology from Banaras Hindu University India, Dr. Sethi joined University of Texas MD Anderson Cancer Center, and worked in the area of inflammation and cancer research for his post-doctoral studies. He later joined National University of Singapore in 2008 as an Assistant Professor and is currently leading the Cancer Pharmacology program in the Department of Pharmacology.
The focus of his research over the past few years has been to elucidate the mechanism (s) of activation of transcription factors NF-κB and STAT3 by carcinogens and inflammatory agents and the identification of novel inhibitors of NF-κB and STAT3 for prevention of and therapy for cancer. From natural sources, his group has identified numerous small molecules that can suppress NF-κB and STAT3 activation and inhibit TNF/IL-6 signaling. Thus, these agents have potential treatment properties for numerous inflammatory diseases, including cancer and are not toxic. Moreover, the results his research work have so far resulted in more than hundred scientific publications in high impact factor peer reviewed journals and several international research awards.