Journal of Surgery and Anesthesia

Department of Anaesthesiology and Intensive Care, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana

Publications

• Research Article   
  Is Lignocaine Preconditioning Effective to Treat Severe Pulmonary Vasoconstriction Induced by Protamine During Cardiac Surgery?
  Author(s): Sanjeev Singh* and Anbarasu Annamalai
  
  Protamine is a low molecular weight protein fraction (5.5-13.0 kDa) that is rich in basic arginine (67%) and lysine amino acids. They are basic polypeptides that neutralize the strongly negatively charged heparin. This study was aimed to explore the effect of lignocaine preconditioning on protamine-induced pulmonary vasoconstriction, which is used to reverse the effect of heparin during cardiac surgery. This was a prospective, single-centre, double-blind and randomised study performed among eighty paediatric patients of either sex in the age group between 1 to 12 years with acyanotic congenital heart disease, scheduled for elective on-pump cardiac surgery under general anaesthesia. The study participants were divided into four groups: Group A non-pulmonary hypertension+lignocaine preconditioning, group B- non-pulmonary hypertension+normal saline preconditioning, g.. View more»
  

  DOI: 10.35248/2684-1606.21.5.148

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