Department of Cardiac Anaesthesia, National Heart Centre, Royal Hospital, Muscat, Oman
Research Article
Is Lignocaine Preconditioning Effective to Treat Severe Pulmonary Vasoconstriction Induced by Protamine During Cardiac Surgery?
Author(s): Sanjeev Singh* and Anbarasu Annamalai
Protamine is a low molecular weight protein fraction (5.5-13.0 kDa) that is rich in basic arginine (67%) and lysine amino
acids. They are basic polypeptides that neutralize the strongly negatively charged heparin. This study was aimed to explore
the effect of lignocaine preconditioning on protamine-induced pulmonary vasoconstriction, which is used to reverse the
effect of heparin during cardiac surgery. This was a prospective, single-centre, double-blind and randomised study performed
among eighty paediatric patients of either sex in the age group between 1 to 12 years with acyanotic congenital heart disease,
scheduled for elective on-pump cardiac surgery under general anaesthesia. The study participants were divided into four
groups: Group A non-pulmonary hypertension+lignocaine preconditioning, group B- non-pulmonary hypertension+normal
saline preconditioning, g.. View more»