Department of Molecular and Cellular Medicine, Institute of Liver and Biliary Sciences, New Delhi, India
Perspective
A Prospective: Hepatitis B Virus X Protein could be a Therapeutic Target for the Cure of Hepatitis B Virus Infection
Author(s): Purnima Tyagi, Akhilesh Kumar Saini and Jitendra Kumar*
Cirrhosis and hepatocellular cancer are linked to chronic hepatitis B infection. Virus replication necessitates the HBx
(Hepatitis B Viral protein). Therapeutic targeting of Hepatitis B Virus (HBV) infection via its protein X (HBx) has emerged
as a promising strategy for combating HBV. This article examines the prospective benefits and difficulties of targeting
HBV infection with HBx, highlighting its implications for future therapeutic interventions. HBx-targeted therapies have
the potential to revolutionise the treatment landscape for chronic HBV infection by interfering with viral replication and
reducing HBx-induced pathogenesis. To completely realise the potential of HBx-targeted therapies, challenges such as HBx
variability, off-target effects, and successful clinical translation must be addressed. Collaboration among researchers, clinicians,
and policymaker.. View more»