Onasanya SS

Department of Pharmaceutical Technology, Moshood Abiola Polytechnic, Abeokuta, Ogun State, Nigeria

Publications
  • Research Article   
    Anti-Diabetic Effect of Methanolic Extract of Aristolochia ringensLeaf
    Author(s): Rasidat O Tijani*, Lawal SO, Oyekan JO, Koleoso OK, Onasanya SS and Fasasi AA

    The aim and objective of this study is to investigate the hypoglycemic, hepatoprotective, hypolipidemic and antioxidant potentials of the methanolic extract of Aristolochia ringens leaf (MLAR) in STZ-induced diabetic wistar rats. The airdried and powdered leaf of the plant (Aristolochia ringens) was extracted by cold maceration and concentrated. In vitro analysis was carried out by screening the extract for phytochemical constituents and antioxidant activities using different models. In vivo analysis was also carried out by randomly dividing forty eight (48) male wistar rats (140-170 g) into eight groups of six (6) rats each. Group 1 served as control; group 2 received STZ (60 mg/kg wt i.p); groups 3 to 8 served as the treatment group. The animals were sacrificed without anesthesia after 30 days and their blood were collected for biochemical investi.. View more»

    DOI: 10.35248/2161-1009.21.10.397

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