PredOmix Technologies Private Limited Tower B, Gurugram, Haryana, India & PredOmix Health Sciences Private Limited, Singapore
Research Article
Beta-Validation of a Non-Invasive Method for Simultaneous Detection of Early-Stage Female-Specific Cancers
Author(s): Sudhakar Ramamoorthy, Saranya Sundaramoorthy, Ankur Gupta, Zaved Siddiqui, Ganga Sagar, Kanury V.S. Rao, Najmuddin Saquib* and Surapaneni Krishna Mohan*
Aim and Objectives: In this report, we assessed the accuracy of our previously developed method for simultaneous diagnosis
of the four female cancers of the Breast, Endometrium, Cervix, and Ovary, in a clinical set-up with blinded protocol.
Materials and Methods: Our test protocol combined global serum metabolome profiling wherein data was analyzed with
machine learning algorithms to extract metabolite signatures that correlated with early-stage cancers. High-resolution mass
spectrometry was employed to profile the serum metabolome and the resulting data were subjected to a pre-processing
pipeline to obtain the data set. The data was then analyzed using artificial intelligence algorithms to identify early-stage cancer
metabolic signatures.
Results: Overall, a total of 1000 blinded samples were analyzed b.. View more»