Journal of Clinical & Experimental Pharmacology

Department of Pharmacology, School of Pharmacy, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia

Publications

• Review Article   
  Altered Sarcoplasmic Reticulum Calcium Cycling-Targets for Heart Failure Therapy
  Author(s): Zemene Demelash Kifle* and Mohammedbrhan Abdelwuhab
  
  Heart failure is a complex clinical syndrome with typical symptoms and signs that generally occur on exertion but can also occur at rest (particularly when recumbent), secondary to an abnormality of cardiac structure or function. There are an estimated 23 million people with HF worldwide. The contractile force in cardiomyocytes is determined by the amplitude of the Ca2+ transient generated by SR Ca2+ release via intracellular Ca2+ release channels/ryanodine receptor-2. At the cellular level, the causes of impaired cardiac myocyte relaxation include cytosolic Ca2+ overload, myofilament structural changes or dysfunction, and neurohormonal activation. Alternatively, a decrease in Ca2+ efflux or inadequate Ca2+ reuptake by the sarcoplasmic reticulum during diastole can result in intracellular Ca2+ overload in this condition. SERCA2a is validated to be the major cardia.. View more»
  

  Abstract PDF