Mélanie Viltard

Dr, Fondation Pour La Recherche En Physiologie, Brussels, Belgium

Publications
  • Review Article   
    Healthy Aging Biology, Powerful Insight from the Long-Lived Naked Mole-Rat
    Author(s): Frédéric Saldmann, Mélanie Viltard*, Christine Leroy, Patrice Codogno and Gérard Friedlander

    The naked mole-rat, Heterocephalus glaber, is the longest-lived rodent known with a lifespan in captivity >30 years, 10 times longer than mice, a comparable size rodent. In addition to a particularly long life, it exhibits exceptional resistance to many age-related diseases: cancer, cardiovascular, neurodegenerative, and metabolic diseases. It resists many forms of stress: hypoxia, oxidative stress, and strikingly maintains adequate body composition, fertility, bone quality, and mineral density throughout their long life. The naked mole-rat is a non-traditional animal model that defies the law governing the processes of aging and mortality and provides a powerful tool for the discovery of endogenous molecular anti-aging pathways. Over the past decades, much possible resistance and anti-aging mechanisms have been discovered. These include exclusive physiologica.. View more»

    DOI: 10.35248/2329-8847.21.9.258

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