President and CEO, GALLY International Biomedical Research Institute
Dr. Gjumrakch Aliev, M.D, Ph.D., the internationally recognized founder of Gally International, has more than a decade of research in the area of gerontology. Dr. Alievs extensive research is respected throughout the world and held in the highest regard. Dr. Aliev is one of the few scientists internationally recognized for his expertise in vascular and mitochondria factors in the pathogenesis of gerontology research fields especially in the atherosclerosis, ischemia/reperfusion, stroke, AD and on the models representing these conditions. In 1982 Gjumrakch Aliev graduated summa cum laude from the Azerbaijan Medical Institute in Baku, Azerbaijan receiving a M.D. degree in the fields of general medicine and health sciences. In 1989, he received his PhD (Summa Cum Laude) in the field of Cardiovascular Biology and Pathology, from the Ivanovo Medical Institute, Department of Electron Microscopy and Cell Pathology of the Institute of Human Morphology, Moscow State University, and Russian Cardiology Research Center, Moscow, Russia. He received postdoctoral training under the prestigious British Hearth Foundation Grant Program in the University College London (advisor Professor Geoffrey Burnstock, FRS) in the specialty neurosciences cardiology and medicine. Professor Aliev have developed research and educational programs in neuroscience, neurodegeneration, mitochondrial, cardiovascular, cerebrovascular, pathology, anatomy, histology, cancer, electron microscopy and other areas. Additionally, he has extensive experience managing dynamic academic research and teaching environments.
Cell Biology, Biochemistry, and Functional Morphology of Cell and Tissues: Endothelial cells, Smooth Muscle Cells; Neurons and as well as Glial and Macrophages Cells; Specific characteristic changes of cell biochemical properties and morphology in different functional states; particularly atherogenesis, vascular remodeling, hypertension, ischemia/reperfusion, tumor angiogenesis, signal transduction and mitochondria DNA deletion and/or overproliferation during cancer growth, metastases and Alzheimer’s diseases; Regulation biochemical mechanisms of specific nitric oxide synthase (NOS) expression in endothelial and smooth muscle cells and macrophages in vivo and in vitro; At the present time, my lab is investigating the cellular and subcellular ultrastructural and molecular mechanisms of the features in the changes of mitochondria (DNA deletion, Cytochrome C Oxidase activity, redox activity (Fe), as well as protein modification and oxidation (HNE) and RNA (8HOG) oxidation during normal aging, atherosclerosis, tumor angiogenesis, stroke, human AD and transgenic mouse models of AD by using molecular biology and functional and structural methods (e.g., in situ hybridization and immunocytochemistry techniques at the light and electron microscopic levels). In addition, the biochemical properties of these protein activities will also be considered for our future studies.
Dominique Meynial Denis
Dominique Meynial-Denis studied Biochemistry and Molecular Biology at the University Paul Sabatier of Toulouse, France and obtained her Ph.D. degree on intermolecular interactions between drug and plasma proteins followed by magnetic resonance spectroscopy (MRS) at the same University in 1985. Since 1986, she has worked as a scientist at the National Institute of Agricultural Research (INRA) in Clermont-Ferrand in a Department focussing on Human Nutrition. Consequently, she became a Nutritionist and specialised her research on Sarcopenia and Aging in 1994. She applied MRS to metabolic pathways of amino acids in muscle during aging. Dominique Meynial-Denis received a second Ph.D. in 1998 on amino acid fluxes throughout skeletal muscle during aging. More recently, she has mainly been interested in the effect of glutamine supplementation in advanced age. She is a member of the French Society of Enteral and Parenteral Nutrition (SFNEP) and of the European Society of Clinical Nutrition and Metabolism (ESPEN). She is a regular referee to different international nutrition journals.
The effect of glutamine supplementation in advanced age