Journal of Clinical & Experimental Pharmacology

Department of ENT and Head and Neck Surgery, Medanta, The Medicity, Gurugram, India

Publications

• Review Article   
  Balancing Efficacy and Tolerability in Nasal Decongestion: A Rationale for the Oxymetazoline and Dexpanthenol Combination
  Author(s): Samir Bhargava, Prahlad H Prabhudesai, Barin Kumar Roy Chaudhuri, Kumud Kumar Handa, P Harihara Murthy, Nitin Vohra, Vinod Malve* and Ashani Basu
  
  Nasal congestion, a common and burdensome symptom, significantly impairs quality of life. Topical decongestants like oxymetazoline provide effective and rapid localized relief, making them a primary therapeutic choice. A known consideration with this therapy is the potential for nasal dryness, which can impact the overall patient experience. This review explores the rationale for combining oxymetazoline with dexpanthenol to address this. The role of dexpanthenol is purely supportive. By providing essential mucosal hydration as a humectant, it helps to soothe local irritation and directly counteract the dryness associated with decongestant use. This action helps maintain a healthy mucosal environment conducive to the body's natural re.. View more»
  

  DOI: 10.35248/2161-1459.26.16.536

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