Journal of Clinical & Experimental Pharmacology

Department of Clinical Laboratory Sciences, Asmara College of Health Sciences, Asmara, Eritrea

Publications

• Research Article   
  In Vivo Anticoagulant Activity ofM Meriandra dianthera and its Sub-Acute Toxicological Effect on Hematological and Biochemical Parameters in Rabbits
  Author(s): Filmon Kiflezghi Kiflemariam*, Abiel Ghebrehiwet Tewelde, Ali Mahmud Hamid, Bilal Mussa Beshir, Samrawit Negasi Solomon, Tesfu Gonets Eman, Daniel Mebrahtu Abraha, Russom Kahsu, John Issac, Jeevan Jyoti Kaushik and Oliver Akoth Achila
  
  Extraction of potent bioactive compounds from medicinal plants permits the evaluation of their biological activity thereby aiding in the development of an effective drugs with less toxicity. The objective of this study was to evaluate the in vivo anticoagulant activity of Meriandra dianthera and its sub-acute toxicological effect on hematological and biochemical parameters in Rabbits. Adult age-matched white rabbits of both sexes were randomly divided into five groups (n=4). Rabbits of the first, second, and third groups were treated orally with an aqueous extract of Meriandra dianthera at a dose rate of 100 mg/kg, 200 mg/kg, and 400 mg/kg body weight respectively for 14 days. The control groups were treated with normal saline and heparin which served as negative and positive controls respectively. The animals in all groups were observe.. View more»
  

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