Gene Technology

Dr, Division of Oral and Maxillofacial Surgery, Department of Sensory and Motor Organs, School of Medicine, Tottori University, 36-1 Nishi-Cho, Yonago 683, Japan

Publications

• Review Article   
  A Paradigm Shift in Bone Regeneration Therapy: Using Mesenchymal Stem Cells and the CRISPR-Cas9 Technology
  Author(s): Takashi Narai*, Yuji Nakayama*, Isamu Kodani and Kenji Kokura
  
  The current mainstream approach to bone regeneration treatment is autologous bone grafting and artificial bone/ bone substitute materials. However, satisfactory treatment results have not been achieved. There is no doubt that Mesenchymal Stem Cells (MSCs) are a useful "tool" for bone regeneration therapy and use of MSCs has been desired. However, MSCs cells are still not widely used in bone regeneration treatments due to their limited osteogenic differentiation ability and efficiency at the transplanted site. Thus, dissection and control of osteogenic differentiation in molecular and cellular level are keys to overcome this issue. To this end, cellular engineering is one of promising approach for it, and various valuable tools for cellular engineering have been developed in recent years. In particular, Clustered regularly interspaced short palindromic re.. View more»
  

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