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Hideaki Ichihara
Division of Applied Life Sciences, Graduate School of Engineering, Sojo University, Kumamoto, Japan
Publications
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Research Article
In vitro growth-inhibitory effects of DMTAP-containing cationic hybrid liposomes (DMTAP-cHL) on cholangiocarcinoma cells
Author(s): Masaki Okumura, Tomoya Hashimoto, Tomoaki Sakoda, Yoko Matsumoto and Hideaki Ichihara*
Cholangiocarcinoma is difficult to detect at an early stage and is one of the most intractable cancers with a poor prognosis. Because current treatments are associated with problems such as adverse effects and therapeutic resistance, the development of new, highly selective therapeutic approaches is required. In this study, we prepared 1,2-Dimyristoyl-3-Trimethylammonium-Propane (DMTAP)-containing cationic Hybrid Liposomes, designated DMTAP-cHL, and investigated their in vitro anticancer effects on Human Cholangiocarcinoma (HuCCT-1) cells. DMTAP-cHL were prepared by sonication using DMPC, the Polyethylene Glycol (PEG)-based surfactant C12(EO)21, and the cationic lipid DMTAP. Dynamic light scattering analysis revealed that DMTAP-cHL had a hydrodynamic diameter of approximately 30 nm and remained stable for 35 days. Fluorescence polarization analysis showed that DMTAP-cHL exhi.. View more»