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Hari Prasad Sonwani
Department of Pharmacology, Apollo College of Pharmacy, Anjora, Durg, C.G, India
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Research Article
Canine Cerebral Artery Vasodilation Caused by Aminoglycoside Antibiotics: The Mechanism
Author(s): Hari Prasad Sonwani*
In canine cerebral arteries and in cultured cerebrovascular smooth muscle cells activated with Oxyhemoglobin (OxyHb), a blood component linked to the pathophysiology of cerebrovascular spasm, the effects of aminoglycoside antibiotics were investigated. The aminoglycosides reduced isometric tension in cerebral artery rings pre-contracted with OxyHb (10 μM) in a concentration-dependent manner. The relaxation's EC50 values for neomycin, gentamicin, streptomycin, and kanamycin were 0.4 ± 0.1 mM (n=α), 0.53 ± 0.08 mM (n=12), 1.α ± 0.3 mM (n=7), and 3.9 ± 0.5 mM (n=5), respectively. The quantity of positive charges in the molecules is roughly correlated with this potency ranking. Additionally, the contractions to prostaglandin F2a (1 μM) and depolarizing potassium chloride concentrations (α0 mM) were suppressed by the aminog.. View more»