Gerontology & Geriatric Research

Department of Genome Biology, Heidelberg University, Heidelberg, Germany

Publications

• Mini Review   
  Eukaryotic Coupled Dinucleotide Contents Modulate Structural DNA Properties
  Author(s): Georg Hildenbrand*
  
  Dinucleotides are known as determinants for different primary and physiochemical properties of DNA and for restricting affinities of proteins to DNA. It is known that these properties, such as stiffness, and bound proteins, such as transcription factors, have an impact on crucial biological processes like transcription regulation and 3D chromatin organization. As a result, the question arises as to how the vastly different dinucleotide contents of eukaryotic chromosomes can still provide consistent properties that result in comparable functions and threedimensional conformations. In this study, we test the hypothesis that coupled dinucleotide contents moderate each other's effects by influencing properties in opposite directions. We discovered sets of correlated and anticorrelated dinucleotide contents after analysing all chromosomes of eukaryotic species and taking into account b.. View more»
  

  DOI: 10.35248/2167-7182.2023.12.651

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