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Binelli A
Department of Infectious Diseases, Istituto Superiore di Sanita, Rome, Italy
Publications
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Review Article
Lastest Update on Therapeutics Strategies for the New Emerging Covid-19 variants. A Review
Author(s): Liliana Elena Weimer*, Cattari G, Binelli A, Fanales Belasio E, Piras S and Sensi F
The Coronavirus disease 2019 (COVID-19) pandemic has challenged public health around the world. Currently, there is an urgent need to explore antiviral therapeutic targets and effective clinical drugs. Monoclonal antibodies are a type of therapeutic agent under investigation for the treatment of COVID-19. These agents are often created by identifying pathogen-specific B cells of patients who have recently recovered from an infection or by immunizing mice genetically modified to have a humanized immune system and harvesting effective antibodies from them. Once the B cells are identified, the genes of immune globulin heavy and light chains are recovered. These genes are then expressed to produce monoclonal antibodies. Monoclonal antibodies have singular activity against a predetermined target; they therefore differ from convalescent plasma, which consists of polyclonal antibodies in ser.. View more»