Journal of Nutritional Disorders & Therapy

Yukio Nakamura

Publications

• Research Article
  Value Changes in Bone Turnover Markers and Bone Mineral Density Using Ibandronate in Japanese Postmenopausal Osteoporotic Patients
  Author(s): Yukio Nakamura, Shota Ikegami, Yuji Takanashi, Mikio Kamimura, Shigeharu Uchiyama and Hiroyuki Kato Yukio Nakamura, Shota Ikegami, Yuji Takanashi, Mikio Kamimura, Shigeharu Uchiyama and Hiroyuki Kato
  
  There has been no actual clinical report on the changes in bone turnover markers and bone mineral density (BMD) during ibandronate (IBN) treatment with or without vitamin D in Japanese postmenopausal osteoporotic patients. In this study, 48 treatment-naïve primary osteoporotic patients were divided into the IBN group or IBN with alfacalcidol (ALF) group. Bone turnover markers, 1,25(OH)2D3, and whole parathyroid hormone (PTH) were examined just prior to treatment and at 1, 4, 8, 12, 16, and 20 weeks of therapy. BMD was measured at 0 and 16 weeks. Values of TRACP-5b were significantly and continuously lower than baseline after 1 week of treatment in both groups. TRACP-5b values were significantly lower in the IBN group with ALF than in the IBN alone group at 4 and 8 weeks of treatment. Values of BAP were comparable between the groups at all-time points. Lumbar and hip BMD was sligh.. View More»
  DOI: 10.4172/2161-0509.1000188

  Abstract PDF