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Workineh Shibeshi
Workineh Shibeshi
School of Pharmacy, College of Health Sciences,
Addis Ababa
Ethiopia
Publications
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Research
Invivo Anti-Trypanosomal Activity of the Leaf Extracts of Albizia Schimperiana (Fabaceae) Against Trypanosoma Congolense Infection in Mice
Author(s): Amene Tesfaye, Getachew Terefe, Mirutse Giday and Workineh ShibeshiAmene Tesfaye, Getachew Terefe, Mirutse Giday and Workineh Shibeshi
Objectives: The objective of this study was to evaluate effect of dichloromethane (DCM) and methanol (MeOH) extracts of the leaf of Albizia schimperiana against Trypanosoma congolense using in vivo mice models. Methods: The leaf of the plant was extracted by maceration technique using DCM and absolute MeOH to obtain the corresponding crude extracts. The extracts were screened for secondary metabolites and anti-trypanosomal activity of the crude extracts was evaluated at doses of 50, 100, 200 and 400 mg/kg in Swiss albino mice infected with T. congolense isolated from natural infection of cattle. The animals were monitored for test parameters including parasitemia, packed cell volume, rectal temperatures, body weight and survival. Results: The acute toxicity test showed that both .. View More»
DOI: 10.4172/2161-1459.1000171