Journal of Neonatal Biology

van Weissenbruch MM

Publications

• Research Article
  Pain Treatment of Newborns: Paracetamol Rectal Versus Intravenous Administration, A Randomised Open Clinical Trial
  Author(s): Laarman ARC, Ris JM, den Burger JCG, Veldkamp AI2, Swart EL, and van Weissenbruch MM Laarman ARC, Ris JM, den Burger JCG, Veldkamp AI2, Swart EL, and van Weissenbruch MM
  
  Background and aim: Early recognition and treatment of pain is of great importance in the neonatal period. Paracetamol is the most frequent prescribed medicine for pain treatment. Administration of rectal paracetamol has limitations and the effectiveness can be variable in neonates. This study is based on the hypothesis that intravenous (iv) paracetamol is well tolerated, less variable and therefore more reliable in preterm neonates compared to rectal paracetamol. We therefore compared the effectiveness of intravenous and rectal administration in (preterm) neonates during a period of sickness accompanied by pain. Methods: We included 21 neonates with pain, post menstrual age (PMA) of 28-44 weeks. They received paracetamol rectal or intravenous according to Dutch guidelines. Serum concentrations at steady state (t = 0, 0.5, 1, 2, 4, 6 hours) wer.. View More»
  DOI: 10.4172/2167-0897.1000172

  Abstract PDF