Journal of Clinical & Experimental Pharmacology

Tariq Helal Ashour

Publications

• Research Article
  Effect of Vitamin D Supplementation with Pegylated Interferon-α and Ribavirin on Erythrocyte Indices, Iron Parameters and Erythropoietin Expression in Male Wistar Rats
  Author(s): Tariq Helal AshourTariq Helal Ashour
  
  Objectives: To measure the effect of Vitamin D3 (Vit D) on liver and serum iron parameters, erythrocyte indices, serum and kidney Erythropoietin (EPO) in normal rats treated with Pegylated Interferon-α (Peg-INF-α) and Ribavirin (RBV). Materials and Methods: Sixty four male Wistar rats were divided equally into 8 groups. ‘Control’; ‘P’: only received Peg-INF-α; ‘PD’: Peg-INF-α/Vit D; ‘PR’: Peg-INF-α/RBV; ‘PRD’: Peg-INF-α/RBV/Vit D; ‘R’: only received RBV; ‘RD’: RBV/Vit D and ‘VitD’: only received vitamin D3. Peg-INF-α-2a was injected subcutaneously (12 μg/rat/ week) for 4 weeks. RBV (4 mg/rat/day) and Vit D (500 IU/rat/day) were given orally for 5 weeks. Blood samples were collected to measure erythrocyte indices and serum 25 (OH).. View More»
  DOI: 10.4172/2161-1459.1000160

  Abstract PDF