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Solomon Assefa
Solomon Assefa
School of Pharmacy,
P.O. Box 1176, Addis Ababa
Ethiopia
Publications
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Research Article
Antimalarial Potential of the Leaf Exudate of Aloe macrocarpa Todaro and its Major Constituents against Plasmodium berghei
Author(s): Yitagesu Tewabe and Solomon Assefa Yitagesu Tewabe and Solomon Assefa
Background: Aloe macrocarpa Todaro is one of the Aloe species in Ethiopia where its leaf exudate is traditionally used for the treatment of various ailments, including malaria. Methods: Two pure compounds namely aloin and aloinoside were isolated from the leaf exudate. Further oxidative hydrolysis yielded another compound (aloe-emodin). Four-day suppressive test was employed to evaluate the antimalarial potential of the leaf exudates and isolated compounds as well as aloe-emodin against mice infected with Plasmodium berghei. Results: The leaf exudate of A. macrocarpa showed significant chemosuppression of P. berghei at all dose levels tested compared to the negative control group. At a dose of 400 mg/kg, the leaf exudate of A. macrocarpa, the isolated aloin as well as the semi.. View More»
DOI: 10.4172/2161-1459.1000245