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Shigeharu Uchiyama
Shigeharu Uchiyama
Japan
Publications
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Case Report
Effects of Denosumab Treatment during Early Pregnancy A Case Report
Author(s): Fumihiro Isobe, Yukio Nakamura, Mikio Kamimura, Shigeharu Uchiyama and Hiroyuki KatoFumihiro Isobe, Yukio Nakamura, Mikio Kamimura, Shigeharu Uchiyama and Hiroyuki Kato
Background: Osteoporotic treatment during pregnancy is controversial. Denosumab, a fully human monoclonal antibody against receptor activator of nuclear factor-kB ligand (RANKL), is a potent new bone resorptive inhibitory drug for osteopenic and osteoporotic treatment. There has been no report on the effectiveness or adverse effect after denosumab treatment in a young osteoporotic patient. Case: We experienced a young lady with osteoporosis due to idiopathic menstrual irregularity. Prior to the therapy, we confirmed that she would not be pregnant during the treatment. Denosumab among numerous drugs after the careful discussion was given who completed delivery without any serious complications for mother or child. We regularly examined the values of bone chemical markers during and after pregnancy, and the bone mineral density (BMD) before tr.. View More»
DOI: 10.4172/2161-0509.1000189