Pharmaceutica Analytica Acta

Mwangi J Mukundi

Publications

• Research Article
  Potential Anti-diabetic Effects and Safety of Aqueous Extracts of Urtica dioica Collected from Narok County, Kenya
  Author(s): Mwangi J Mukundi, Njagi EN Mwaniki, Ngugi M Piero, Njagi J Murugi, Juma K Kelvin, Abdirahman A Yusuf, Mwonjoria K John, Ngetich K Alex, Agyirifo S Daniel, Gathumbi K Peter and Muchugi N AliceMwangi J Mukundi, Njagi EN Mwaniki, Ngugi M Piero, Njagi J Murugi, Juma K Kelvin, Abdirahman A Yusuf, Mwonjoria K John, Ngetich K Alex, Agyirifo S Daniel, Gathumbi K Peter and Muchugi N Alice
  
  Drug bio screening for potential anti-diabetics is scientifically motivated by the desire to discover newer, safer and affordable drugs that complement conventional strategies for management of diabetes. Urtica dioica grows naturally in many parts of Africa with a wide variety use in traditional medicine and diet. However, scientific validation for use of U. dioica has not been done for anti-diabetic activity. The aim of the study was to determine the antidiabetic effects of aqueous extracts of U. dioica in alloxan induced mice and the safety of U. dioica on mice models. The plant extracts were administered orally at doses of 25 mg/kg, 100 mg/kg, 200 mg/kg and 300 mg/kg which is the common route used in traditional herbal medicine administration. Evaluation for toxicity was determined at a dose of 1000 mg/kg body weight aqueous extracts of U. dioica. The results from the study indicated .. View More»
  DOI: 10.4172/2153-2435.1000548

  Abstract PDF