Journal of Clinical & Experimental Pharmacology

Mustafa Ahmed Alshagga

Publications

• Research Article
  In vitro and In vivo Study of Effect of α-Adrenergic Agonist-Methyldopa on the Serum Biochemical Laboratory Findings
  Author(s): Ibrahim Abdel Aziz Ibrahim*,Naiyer Shahzad,Fawwaz S. Al-Joudi,Saeed S. Al-Ghamdi,Mustafa Ahmed Alshagga,Nehad M. HammodiIbrahim Abdel Aziz Ibrahim*,Naiyer Shahzad,Fawwaz S. Al-Joudi,Saeed S. Al-Ghamdi,Mustafa Ahmed Alshagga,Nehad M. Hammodi
  
  Objectives: The effects of the antihypertensive drug methyldopa on biochemical laboratory findings were monitored both in vitro and in vivo particularly those of metabolites and enzymes which are routinely requested by physicians. Methods: In vitro and in vivo studies were performed. For the in vitro study, solutions of methyldopa concentrations were prepared according to its maximum serum concentration as reported in the literature and were added to blank, normal serum. The samples were then analyzed in parallel with a standard test using the same laboratory techniques. For the in vivo study, blood was collected before starting and two weeks after starting methyldopa therapy from 40 subjects that were newly diagnosed with essential hypertension. The control sera were collected from 30 healthy volunteers of comparable ages. The samples were analyzed for glucose, Total Protein (T.. View More»
  DOI: 10.4172/2161-1459.1000136

  Abstract PDF