Journal of Clinical & Experimental Pharmacology

Muchchandi IS

Publications

• Research Article
  Protective Effect of Punica granatum L. on Gentamicin Induced Acute Renal Failure in Adult Rats
  Author(s): Rathod NS,Halagali KS,Nidavani RB,Shalavadi MH,Biradar BS,Biswas D*,Chandrashekhar VM,Muchchandi ISRathod NS,Halagali KS,Nidavani RB,Shalavadi MH,Biradar BS,Biswas D*,Chandrashekhar VM,Muchchandi IS
  
  Aim: Study was undertaken to evaluate the effect of Punica granatum L. on Gentamicin-induced renal failure in rats. Materials and methods: Gr. I rats served as normal, received 0.5 ml of 5% Tween-80 in distilled water, Gr. II was injected with Gentamicin (100 mg/kg, IP), Gr. III was injected with Gentamicin and selenium (2 mg/kg, IP), and Gr. IV-IX were given orally Punica granatum fruit chloroform extract (PGCE) and Punica granatum methanol extract (PGME) at the doses of 100, 200 and 400 mg/kg, respectively, were administered for eight days in Gentamicininduced renal failure rats. On last day, Blood and 24 h urine was collected and used for estimation of serum and urine creatinine, urea, uric acid levels. The kidney homogenate was used for the estimation of LPO, SOD, CAT and GSH levels and Kidney sections were analyzed for histopathology. Results: Gentamicin-induced (Gr. II) had sign.. View More»
  DOI: 10.4172/2161-1459.1000210

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