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Mohammad Adnan
Mohammad Adnan
Bangladesh
Publications
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Review Article
Anticancer Agents in Combination with Statins
Author(s): Mohammad Adnan, Kabir Imtiazul Mohammad and Mohammad Emdad Hossain ManikMohammad Adnan, Kabir Imtiazul Mohammad and Mohammad Emdad Hossain Manik
Statins are 3-Hydroxy-3-methylgutaryl CoA (HMG CoA) reductase inhibitors and mainly used in cardiovascular diseases. However, they are also widely known for their anticancer activities mediated by antiproliferative, proapoptotic, anti-invasive, and radio sensitizing properties. They are tested alone in several clinical trials for their anticancer activity and the response in not satisfactory due to high dose requirements in humans. Tumor inhibitory concentration of statins is 10-100 μM for different cancer cell lines when tested in vitro. But statins can cause anorexia and death in some individuals if concentration is reached to 20-25 μM in serum. So, there is high risk factor. To avoid these unwanted harmful effects, we can give statins in combination with other chemotherapeutic drugs for synergism. It will reduce the concentration of statins in dosage, and can avoid unwanted t.. View More»
DOI: 10.4172/jbb.1000345