Journal of Clinical & Experimental Pharmacology

Martínez-Rodríguez Leonardo A

Publications

• Research Article
  Siliphos Selenium Methionine Alpha Lipoic Acid for Non Alcoholic Fatty Liver Disease: Results of a Pilot Study
  Author(s): Martínez-Rodríguez Leonardo A,Rojas Serrano Jorge,Aldo Torre*Martínez-Rodríguez Leonardo A,Rojas Serrano Jorge,Aldo Torre*
  
  Siliphos-selenium-methionine-alpha lipoic acid (SSMAL) has been used to treat chronic hepatic diseases, although formal evaluation of this mixture with clinical trials is lacking. We conduct this pilot study to investigate the safety and effectiveness of SSMAL in patients with non-alcoholic fatty liver disease (NAFLD). Forty NAFLD patients were randomized into two groups. All patients received metformin 1500 mg q.a.d. added to nutritional and exercise advice. Twenty patients received selenium (15 mcg) – methionine (3 mg)-alpha lipoic acid (200 mg) group. After 24 weeks, basal versus final biochemical and image studies were compared. Patients from SSMAL group, had a decrease in steatosis graded by ultrasound 70% vs. 15% (p<0.001) and showed lower rates of liver enzymes than control group. Pro-inflammatory cytokines profile and the reduced antioxidant status noted in NAFLD pati.. View More»
  DOI: 10.4172/2161-1459.1000167

  Abstract PDF